| Title : Lipase-catalyzed synthesis of ethyl (R)-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods - Ding_2019_Biosci.Biotechnol.Biochem__1 |
| Author(s) : Ding J , Yang Z , Zhao Y , Fang W , Lu Q |
| Ref : Biosci Biotechnol Biochem , :1 , 2019 |
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Abstract :
Ethyl (R)-2-benzyloxy-2-isopropylhydrogenmalonate is a key intermediate for the synthesis of the side chain in ergopeptines. In this work, we adopted a method to prepare enantiomerically pure title monoester via immobilized Candida antarctica lipase B (Novozym 435)-catalyzed hydrolysis of the corresponding diester. |
| PubMedSearch : Ding_2019_Biosci.Biotechnol.Biochem__1 |
| PubMedID: 30654732 |
Ding J, Yang Z, Zhao Y, Fang W, Lu Q (2019)
Lipase-catalyzed synthesis of ethyl (R)-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods
Biosci Biotechnol Biochem
:1
Ding J, Yang Z, Zhao Y, Fang W, Lu Q (2019)
Biosci Biotechnol Biochem
:1