| Title : A 2-methyleneoxetane analog of orlistat demonstrating inhibition of porcine pancreatic lipase - Dollinger_1998_Bioorg.Med.Chem.Lett_8_977 |
| Author(s) : Dollinger LM , Howell AR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 8 :977 , 1998 |
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Abstract :
The 2-methyleneoxetane analog 2 of orlistat (OLS, 1) has been synthesized and tested against porcine pancreatic lipase (PPL). Despite the loss of the carbonyl group, a potential site for hydrogen bonding interaction with the enzyme and the key element in the acylation by OLS, 2 has activity comparable to 1. |
| PubMedSearch : Dollinger_1998_Bioorg.Med.Chem.Lett_8_977 |
| PubMedID: 9871523 |
| Gene_locus related to this paper: pig-1plip |
| Gene_locus | pig-1plip |
Dollinger LM, Howell AR (1998)
A 2-methyleneoxetane analog of orlistat demonstrating inhibition of porcine pancreatic lipase
Bioorganic & Medicinal Chemistry Lett
8 :977
Dollinger LM, Howell AR (1998)
Bioorganic & Medicinal Chemistry Lett
8 :977