| Title : Proaporphine and aporphine alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea - Dong_2015_Fitoterapia_104_102 |
| Author(s) : Dong JW , Cai L , Fang YS , Xiao H , Li ZJ , Ding ZT |
| Ref : Fitoterapia , 104 :102 , 2015 |
|
Abstract :
An unusual proaporphine alkaloid bearing an isopropanenitrile group at isoquinoline nitrogen, named epiganine A (1) and a new aporphine alkaloid, epiganine B (2), together with eight known alkaloids, pronuciferine (3), dehydrodicentrine (4), romerine (5), romeline (6), N-methylcalycinine (7), phanostenine (8), dicentrine (9), and N-methyllaurotetanine (10), were isolated from the roots of Stephania epigaea. The absolute configuration of 1 was determined by calculating electronic circular dichroism (ECD) and comparing with experimental data. Compounds 2 and 4 showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 values of 4.36 and 2.98muM, respectively. Compounds 5-9 also exhibited potent AChE inhibitory activities. |
| PubMedSearch : Dong_2015_Fitoterapia_104_102 |
| PubMedID: 26028544 |
Dong JW, Cai L, Fang YS, Xiao H, Li ZJ, Ding ZT (2015)
Proaporphine and aporphine alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea
Fitoterapia
104 :102
Dong JW, Cai L, Fang YS, Xiao H, Li ZJ, Ding ZT (2015)
Fitoterapia
104 :102