Dorko_1998_Bratisl.Lek.Listy_99_258

Surgical and chemical castrations in old rats result in the regeneration of the involuted thymus. The distribution of ACHE-positive nerves did not differ in the regenerated thymi after surgical and chemical castrations. A number of ACHE-positive nerves were detected not only in perivascular topography but also in the functioning thymus parenchyma. A marked difference in thymus density of ACHE-positive nerves was found in rats without castration. We assume that our findings represent an indirect evidence that cholinergic nerves stimulate lymphopoiesis in the thymus. (Fig. 6, Ref. 16.)