Du_2009_Med.Hypotheses_73_662

Reference

Title : Therapeutic potential of lipase inhibitor orlistat in Alzheimer's disease - Du_2009_Med.Hypotheses_73_662
Author(s) : Du J , Wang Z
Ref : Med Hypotheses , 73 :662 , 2009
Abstract :

Emerging evidences indicate that elevated cholesterol and triglyceride levels precede Alzheimer's disease (AD) pathology. High caloric intake based on saturated fat raises hyperlipidaemia and also promotes AD pathology. As a result, strategy that limits the absorption of dietary fat and attenuates hyperlipidemia could be a useful medication for protective treatment of AD. As an active site-directed inhibitor of digestive lipases, orlistat effectively reduces dietary fat absorption and decreases total cholesterol and triglyceride levels in plasma. Orlistat also potently inhibits lipoprotein lipase, monoacylglycerol lipase and diacylglycerol lipase, which are also involved in AD causation. Taken together, orlistat inhibits lipases activities, thereby reduces dietary fat intake and ameliorates hyperlipidemia, which indicates a therapeutic potential of orlistat in protecting against AD pathology.

PubMedSearch : Du_2009_Med.Hypotheses_73_662
PubMedID: 19505770

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Citations formats

Du J, Wang Z (2009)
Therapeutic potential of lipase inhibitor orlistat in Alzheimer's disease
Med Hypotheses 73 :662

Du J, Wang Z (2009)
Med Hypotheses 73 :662