| Title : Coumarins from Sarcandra glabra (Thunb.) Nakai and Acetylcholinesterase Inhibiting Activity - Du_2022_Chem.Biodivers__ |
| Author(s) : Du NN , Bai M , Zhang X , Zhou L , Huang XX , Song SJ |
| Ref : Chem Biodivers , : , 2022 |
|
Abstract :
Nine coumarins including a pair of new enantiomers ( 1a / 1b ) and seven known compounds ( 2-8 ) were isolated from Sarcandra glabra (Thunb.) Nakai. Among them, compounds 1a and 1b were naturally occurring coumarin-phenylpropanoid conjugate enantiomers. Their structures were identified by NMR and ECD calculations. Compounds 1-8 were tested for acetylcholinesterase (AchE) inhibiting activity. The results of the enzymology experiment showed that compound 3 demonstrated obvious AchE inhibitory activity which showed an IC 50 value of 1.982 +/- 0.003 micro M, and the binding sites were predicted by molecular docking. |
| PubMedSearch : Du_2022_Chem.Biodivers__ |
| PubMedID: 36036517 |
Du NN, Bai M, Zhang X, Zhou L, Huang XX, Song SJ (2022)
Coumarins from Sarcandra glabra (Thunb.) Nakai and Acetylcholinesterase Inhibiting Activity
Chem Biodivers
:
Du NN, Bai M, Zhang X, Zhou L, Huang XX, Song SJ (2022)
Chem Biodivers
: