| Title : Studies on the efficacy of diethyxime as an antidote against organophosphorus intoxication in rats - Dube_1986_Jpn.J.Pharmacol_41_267 |
| Author(s) : Dube SN , Ghosh AK , Jeevarathinam K , Kumar D , Das Gupta S , Pant BP , Batra BS , Jaiswal DK |
| Ref : Japanese Journal of Pharmacology , 41 :267 , 1986 |
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Abstract :
Diethyxime, a non-quaternary cholinesterase reactivator was evaluated for its antidotal efficacy against organophosphorus intoxication in rats using the protection index, cholinesterase reactivation and neuromuscular function as the experimental protocol. Diethyxime along with atropine produced a marked antidotal effect against dimethyl dichlorovinyl phosphate (DDVP) poisoning on all the parameters studied. The action of diethyxime was mainly peripheral. The protective efficacy against diisopropyl fluorophosphate (DFP) poisoning was not observed with this reactivator. |
| PubMedSearch : Dube_1986_Jpn.J.Pharmacol_41_267 |
| PubMedID: 3761745 |
Dube SN, Ghosh AK, Jeevarathinam K, Kumar D, Das Gupta S, Pant BP, Batra BS, Jaiswal DK (1986)
Studies on the efficacy of diethyxime as an antidote against organophosphorus intoxication in rats
Japanese Journal of Pharmacology
41 :267
Dube SN, Ghosh AK, Jeevarathinam K, Kumar D, Das Gupta S, Pant BP, Batra BS, Jaiswal DK (1986)
Japanese Journal of Pharmacology
41 :267