| Title : Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity - Dung_2015_Arch.Pharm.Res_38_677 |
| Author(s) : Dung HV , Cuong TD , Chinh NM , Quyen D , Kim JA , Byeon JS , Woo MH , Choi JS , Min BS |
| Ref : Arch Pharm Res , 38 :677 , 2015 |
|
Abstract :
A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 muM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 muM. |
| PubMedSearch : Dung_2015_Arch.Pharm.Res_38_677 |
| PubMedID: 25005067 |
Dung HV, Cuong TD, Chinh NM, Quyen D, Kim JA, Byeon JS, Woo MH, Choi JS, Min BS (2015)
Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity
Arch Pharm Res
38 :677
Dung HV, Cuong TD, Chinh NM, Quyen D, Kim JA, Byeon JS, Woo MH, Choi JS, Min BS (2015)
Arch Pharm Res
38 :677