| Title : Structure-activity relationship for aryl and heteroaryl boronic acid inhibitors of hormone-sensitive lipase - Ebdrup_2005_Bioorg.Med.Chem_13_2305 |
| Author(s) : Ebdrup S , Jacobsen P , Farrington AD , Vedso P |
| Ref : Bioorganic & Medicinal Chemistry , 13 :2305 , 2005 |
|
Abstract :
A range of aryl and heteroaryl boronic acids were tested for their in vitro hormone-sensitive lipase inhibitory properties. (2-Benzyloxy-5-fluorophenyl)boronic acid, (2-benzyloxy-5-chlorophenyl)boronic acid and 5-bromothiophene-2-boronic acid were found to be the most potent HSL inhibitors with IC(50) values of 140, 17 and 350 nM, respectively. |
| PubMedSearch : Ebdrup_2005_Bioorg.Med.Chem_13_2305 |
| PubMedID: 15727879 |
Ebdrup S, Jacobsen P, Farrington AD, Vedso P (2005)
Structure-activity relationship for aryl and heteroaryl boronic acid inhibitors of hormone-sensitive lipase
Bioorganic & Medicinal Chemistry
13 :2305
Ebdrup S, Jacobsen P, Farrington AD, Vedso P (2005)
Bioorganic & Medicinal Chemistry
13 :2305