| Title : In vivo turnover rate of acetylcholine in rat brain parts at elevated steady-state concentration of plasma choline - Eckernas_1977_Acta.Physiol.Scand_101_404 |
| Author(s) : Eckernas SA , Sahlstrom L , Aquilonius SM |
| Ref : Acta Physiologica Scandinavica , 101 :404 , 1977 |
|
Abstract :
Cortical and striatal turnover rates of acetylcholine TR(ACh) were estimated by applying steady-state tracer kinetics in rats killed by microwave irradiation following a constant i.v. infusion of 3H-Ch. In control rats TR(ACh) was 3.6 nmol . g-1 . min-1 in the cortex and 23.8 nmol . g-1 . min-1 in the striatum. When steady-state plasma concentrations of Ch were increased from 17 to 140 mumol . 1-1 by a 15-min infusion of unlabelled Ch the corresponding TR(ACh) were 3.6 nmol . g-1 . min-1 and 21.4 nmol . g-1 . min-1, respectively. These results indicate that increased plasma levels of Ch are not accompanied by increased synthesis of brain ACh. |
| PubMedSearch : Eckernas_1977_Acta.Physiol.Scand_101_404 |
| PubMedID: 596215 |
Eckernas SA, Sahlstrom L, Aquilonius SM (1977)
In vivo turnover rate of acetylcholine in rat brain parts at elevated steady-state concentration of plasma choline
Acta Physiologica Scandinavica
101 :404
Eckernas SA, Sahlstrom L, Aquilonius SM (1977)
Acta Physiologica Scandinavica
101 :404