Title : Hydroxynitrile lyases in stereoselective catalysis - Effenberger_2000_Curr.Opin.Biotechnol_11_532 |
Author(s) : Effenberger F , Forster S , Wajant H |
Ref : Curr Opin Biotechnol , 11 :532 , 2000 |
Abstract :
(R)- as well as (S)-cyanohydrins are now easily available as a result of the excellent accessibility, the relatively high stability and the easy handling of hydroxynitrile lyases (HNLs). The optimization of reaction conditions (solvent, temperature, and using site-directed mutagenesis, etc.) has enabled HNL-catalyzed preparations of optically active cyanohydrins on a technical scale. The enantioselectivity of chiral metal-complex-catalyzed additions of trimethylsilyl cyanide to aldehydes has been improved, but is, by far, not yet competitive with the HNL-catalyzed reactions. |
PubMedSearch : Effenberger_2000_Curr.Opin.Biotechnol_11_532 |
PubMedID: 11102786 |
Effenberger F, Forster S, Wajant H (2000)
Hydroxynitrile lyases in stereoselective catalysis
Curr Opin Biotechnol
11 :532
Effenberger F, Forster S, Wajant H (2000)
Curr Opin Biotechnol
11 :532