Egea_1989_Neurosci_31_521

Reference

Title : Increase in reactive cholesterol in the presynaptic membrane of depolarized Torpedo synaptosomes: blockade by botulinum toxin type A - Egea_1989_Neurosci_31_521
Author(s) : Egea G , Marsal J , Solsona C , Rabasseda X , Blasi J
Ref : Neuroscience , 31 :521 , 1989
Abstract :

We have investigated the redistribution of filipin-cholesterol complexes at freeze-fractured presynaptic membrane of pure cholinergic synaptosomes isolated from Torpedo electric organ during acetylcholine release. After chemical depolarization, filipin-induced lesions increase at the presynaptic membrane. These changes do not take place when synaptosomes are stimulated in a calcium-free medium. Botulinum neurotoxin type A blocks both acetylcholine release and the rearrangement of filipin-induced lesions induced by depolarization. Since botulinum neurotoxin type A does not block either membrane depolarization or calcium entry into the nerve terminal, our results suggest that the redistribution of filipin-cholesterol complexes is linked to the acetylcholine release process.

PubMedSearch : Egea_1989_Neurosci_31_521
PubMedID: 2797448

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Citations formats

Egea G, Marsal J, Solsona C, Rabasseda X, Blasi J (1989)
Increase in reactive cholesterol in the presynaptic membrane of depolarized Torpedo synaptosomes: blockade by botulinum toxin type A
Neuroscience 31 :521

Egea G, Marsal J, Solsona C, Rabasseda X, Blasi J (1989)
Neuroscience 31 :521