| Title : Biosynthetic origin of a branched chain analogue of the lipase inhibitor, lipstatin - Eisenreich_2003_J.Med.Chem_46_4209 |
| Author(s) : Eisenreich W , Kupfer E , Stohler P , Weber W , Bacher A |
| Ref : Journal of Medicinal Chemistry , 46 :4209 , 2003 |
|
Abstract :
The lipophilic beta-lactone, lipstatin, inhibits pancreatic lipase and has been shown earlier to be biosynthesized by Claisen condensation of two fatty acid moieties. We present data from incorporation experiments with [U-13C6]leucine showing that a branched chain analogue of lipstatin is biosynthesized from leucine. |
| PubMedSearch : Eisenreich_2003_J.Med.Chem_46_4209 |
| PubMedID: 12954074 |
Eisenreich W, Kupfer E, Stohler P, Weber W, Bacher A (2003)
Biosynthetic origin of a branched chain analogue of the lipase inhibitor, lipstatin
Journal of Medicinal Chemistry
46 :4209
Eisenreich W, Kupfer E, Stohler P, Weber W, Bacher A (2003)
Journal of Medicinal Chemistry
46 :4209