El Manira_2014_Neuron_83_515

In this issue of Neuron, three papers, Severi et al. (2014), Thiele et al. (2014), and Wang and McLean (2014), examine the descending circuitry involved in coordinating locomotor behavior in larval zebrafish. Visually evoked locomotor and steering movements in zebrafish are mediated by neurons in the nucleus of the medial longitudinal fascicle (nMLF) that project directly to spinal motoneurons. The final motor output induced by nMLF will involve integration in the hindbrain and premotor circuits in the spinal cord.