Title : Synaptic strength regulated by palmitate cycling on PSD-95 - El-Husseini_2002_Cell_108_849 |
Author(s) : El-Husseini Ael D , Schnell E , Dakoji S , Sweeney N , Zhou Q , Prange O , Gauthier-Campbell C , Aguilera-Moreno A , Nicoll RA , Bredt DS |
Ref : Cell , 108 :849 , 2002 |
Abstract :
Dynamic regulation of AMPA-type glutamate receptors represents a primary mechanism for controlling synaptic strength, though mechanisms for this process are poorly understood. The palmitoylated postsynaptic density protein, PSD-95, regulates synaptic plasticity and associates with the AMPA receptor trafficking protein, stargazin. Here, we identify palmitate cycling on PSD-95 at the synapse and find that palmitate turnover on PSD-95 is regulated by glutamate receptor activity. Acutely blocking palmitoylation disperses synaptic clusters of PSD-95 and causes a selective loss of synaptic AMPA receptors. We also find that rapid glutamate-mediated AMPA receptor internalization requires depalmitoylation of PSD-95. In a nonneuronal model system, clustering of PSD-95, stargazin, and AMPA receptors is also regulated by ongoing palmitoylation of PSD-95 at the plasma membrane. These studies suggest that palmitate cycling on PSD-95 can regulate synaptic strength and regulates aspects of activity-dependent plasticity. |
PubMedSearch : El-Husseini_2002_Cell_108_849 |
PubMedID: 11955437 |
El-Husseini Ael D, Schnell E, Dakoji S, Sweeney N, Zhou Q, Prange O, Gauthier-Campbell C, Aguilera-Moreno A, Nicoll RA, Bredt DS (2002)
Synaptic strength regulated by palmitate cycling on PSD-95
Cell
108 :849
El-Husseini Ael D, Schnell E, Dakoji S, Sweeney N, Zhou Q, Prange O, Gauthier-Campbell C, Aguilera-Moreno A, Nicoll RA, Bredt DS (2002)
Cell
108 :849