Elaeva_1997_Eksp.Klin.Farmakol_60_64

Reference

Title : [The pharmacokinetic interaction of cholinolytics and cholinesterase reactivators as a reflection of the modulation of their binding in blood plasma and in brain tissue] - Elaeva_1997_Eksp.Klin.Farmakol_60_64
Author(s) : Elaeva NL , Predtechenskii MB , Kul'bitskii GN , Babaina EV , Trefilov VV
Ref : Eksperimentalnaia i Klinicheskaia Farmakologiia , 60 :64 , 1997
Abstract :

Radioligand assay showed that the cholinesterase (ChE) reactivators dipiroxime and benzyxime, but not carboxime, modulate selective absorption of some cholinolytics (tributam, pediphen, aprophen) in rat brain. Significant suppression of the specific binding of muscarine antagonists was recorded after chlorophos (2.LD50) intoxication. Under such conditions, the ChE reactivators induce increase in the number of binding sites and in the parameters of the constant of cholinolytic absorption on the brain membranes. It was also established by equilibrium dialysis that the binding of cholinolytics in blood plasma under the effect of ChE reactivators is reduced, leading to redistribution of their free and bound fractures, which is most favorable for tissue sorption.

PubMedSearch : Elaeva_1997_Eksp.Klin.Farmakol_60_64
PubMedID: 9376763

Related information

Citations formats

Elaeva NL, Predtechenskii MB, Kul'bitskii GN, Babaina EV, Trefilov VV (1997)
[The pharmacokinetic interaction of cholinolytics and cholinesterase reactivators as a reflection of the modulation of their binding in blood plasma and in brain tissue]
Eksperimentalnaia i Klinicheskaia Farmakologiia 60 :64

Elaeva NL, Predtechenskii MB, Kul'bitskii GN, Babaina EV, Trefilov VV (1997)
Eksperimentalnaia i Klinicheskaia Farmakologiia 60 :64