Elhalwagy_2015_Int.J.Clin.Exp.Med_8_7297

Reference

Title : Hepatopancreatic intoxication of lambda cyhalothrin insecticide on albino rats - Elhalwagy_2015_Int.J.Clin.Exp.Med_8_7297
Author(s) : Elhalwagy ME , Abd-Alrahman SH , Nahas AA , Ziada RM , Mohamady AH
Ref : Int J Clin Exp Med , 8 :7297 , 2015
Abstract :

BACKGROUND: Despite the known adverse effects of lambda cyhalothrin insecticide, little is known about its hepatopancreatic intoxication effects. The present study was carried out to elucidate sub-chronic effect of Karat 2.5% EC formulation of lambda cyhalothrin on male albino rats.
METHODS: To explore the effects of exposure to lambda cyhalothrin on rats and its mechanism, low (1/40 of LD50, 5 mg/kg/day) and high dose (1/4 of LD50, 50 mg/kg/day) lambda cyhalothrin were applied to rats via drinking water for 3 months. Blood samples were collected monthly, and the animals were dissected for liver and pancreas's examination at the end of the experiment. Lambda cyhalothrin administration was associated with the elevation in lipid peroxidation marker, malondialdehyde (MDA), reduction in SH-protein a major marker for antioxidant, as well as basel paraoxonase (PON) in both treated groups throughout the experimental periods.
RESULTS: In addition, significant elevations in liver enzymes alanin amino transferase, (ALT), and aspartate amino transferase (AST), as well as plasma acetylcholinesterase (AChE) and glucose level. While, significant reduction in insulin level through the experimental periods. Results of histopathological and histochemical studies showed that lambda cyhalothrin exposure induces liver and pancreatic tissues damage and depletion in glycogen content was pronounced in liver of both treated groups.
CONCLUSIONS: In conclusion subchronic intoxication with lambda cyhalothrin formulation induced remarkable changes in the examined parameters.

PubMedSearch : Elhalwagy_2015_Int.J.Clin.Exp.Med_8_7297
PubMedID: 26221269

Related information

Citations formats

Elhalwagy ME, Abd-Alrahman SH, Nahas AA, Ziada RM, Mohamady AH (2015)
Hepatopancreatic intoxication of lambda cyhalothrin insecticide on albino rats
Int J Clin Exp Med 8 :7297

Elhalwagy ME, Abd-Alrahman SH, Nahas AA, Ziada RM, Mohamady AH (2015)
Int J Clin Exp Med 8 :7297