Elsebai_2022_Sci.Rep_12_18351

Reference

Title : X-ray crystalographic data, absolute configuration, and anticholinesterase effect of dihydromyricitrin 3-O-rhamnoside - Elsebai_2022_Sci.Rep_12_18351
Author(s) : Elsebai MF , Ghabbour HA , Salmas RE , Orhan IE , Senol Deniz FS
Ref : Sci Rep , 12 :18351 , 2022
Abstract :

Based on our continuous effort to investigate chemistry and biology of the plant secondary metabolites, we were able to isolate a glycosidal flavonoid 1 from the Wild Egyptian Artichoke. The activity of dihydromyricetin 3-O-rhamnoside (sin. dihydromyricitrin, ampelopsin 3-O-rhamnoside) (1) against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE); its absolute configuration using X-ray crystallography were determined for the first time. Inhibitory activity of 1 against AChE and BChE enzymes were determined using a slightly modified version of Ellman's method. Compound 1 was revealed to have a potent inhibition against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC(50) values of 0.070 +/- 0.008 and 0.071 +/- 0.004 mM, respectively, where IC(50) values of the reference drug (galanthamine) were 0.023 +/- 0.15 and 0.047 +/- 0.91 mM. Compound 1 could be a promising molecule against Alzheimer's disease.

PubMedSearch : Elsebai_2022_Sci.Rep_12_18351
PubMedID: 36319690

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Citations formats

Elsebai MF, Ghabbour HA, Salmas RE, Orhan IE, Senol Deniz FS (2022)
X-ray crystalographic data, absolute configuration, and anticholinesterase effect of dihydromyricitrin 3-O-rhamnoside
Sci Rep 12 :18351

Elsebai MF, Ghabbour HA, Salmas RE, Orhan IE, Senol Deniz FS (2022)
Sci Rep 12 :18351