| Title : Differential effects of 8-bromo-cyclic GMP on the basal contractile force and beta-adrenoceptor-mediated positive inotropic action in the canine atrium - Endoh_1983_Tohoku.J.Exp.Med_140_105 |
| Author(s) : Endoh M |
| Ref : Tohoku J Exp Med , 140 :105 , 1983 |
|
Abstract :
8-Bromo-cyclic GMP caused a negative inotropic action on the canine atrial muscle, whilst it did not affect the positive inotropic action of phenylephrine mediated via beta-adrenoceptors. These findings are in line with the hypothesis that the muscarinic receptor stimulation may exert functional changes in the heart via two different intracellular biochemical processes: one involving cyclic AMP and the other involving cyclic GMP. 8-Bromo-cyclic GMP mimics the latter but not the former mechanism in canine atria. |
| PubMedSearch : Endoh_1983_Tohoku.J.Exp.Med_140_105 |
| PubMedID: 6135262 |
Endoh M (1983)
Differential effects of 8-bromo-cyclic GMP on the basal contractile force and beta-adrenoceptor-mediated positive inotropic action in the canine atrium
Tohoku J Exp Med
140 :105
Endoh M (1983)
Tohoku J Exp Med
140 :105