| Title : Determination of atropine in plasma by a direct radioreceptor assay - Ensing_1987_Pharm.Weekbl.Sci_9_321 |
| Author(s) : Ensing K , de Zeeuw RA , Hornchen U , Schuttler J , Stoeckel H |
| Ref : Pharm Weekbl Sci , 9 :321 , 1987 |
|
Abstract :
A highly sensitive radioreceptor assay for the anticholinergic atropine was developed and could be applied directly to plasma samples obtained from mini-pigs without any clean-up. Plasma samples were collected during 6 h after atropine was administered intravenously or endobronchially. The endobronchial plasma concentration-time curves were characterized by a very rapid rise of the concentration but with a subsequent much slower decrease than after intravenous administration. This indicates an initially high as well as prolonged uptake from the lungs. |
| PubMedSearch : Ensing_1987_Pharm.Weekbl.Sci_9_321 |
| PubMedID: 3432041 |
Ensing K, de Zeeuw RA, Hornchen U, Schuttler J, Stoeckel H (1987)
Determination of atropine in plasma by a direct radioreceptor assay
Pharm Weekbl Sci
9 :321
Ensing K, de Zeeuw RA, Hornchen U, Schuttler J, Stoeckel H (1987)
Pharm Weekbl Sci
9 :321