Ensing_1989_Eur.J.Clin.Pharmacol_36_189

Reference

Title : Pharmacokinetics of ipratropium bromide after single dose inhalation and oral and intravenous administration - Ensing_1989_Eur.J.Clin.Pharmacol_36_189
Author(s) : Ensing K , de Zeeuw RA , Nossent GD , Koeter GH , Cornelissen PJ
Ref : European Journal of Clinical Pharmacology , 36 :189 , 1989
Abstract :

Single doses of ipratropium bromide were administered intravenously, orally and by slow inhalation to ten healthy male volunteers. The plasma level after oral administration followed a low but broad plateau persisting for several hours. After i.v. administration the kinetic parameters were: Vc = 25.9 l, V alpha = 13.1 l, V beta = 3.38 l, t1/2 alpha = 3.85 min, t1/2 beta = 98.4 min, AUC = 15.0 h.ng/ml, kel = 11.8 l/h and total clearance is 2325 ml/min. The bioavailability was 3.3% (range 0.9-6.1%) on comparing the plasma AUCs following i.v. and 20 mg oral administration. The cumulative renal excretion (0-24 h) after i.v. administration was compared with that after oral administration and inhalation. Following oral administration, the apparent systemic availability was around 2%, and after inhalation it was 6.9%. In comparison with oral placebo administration, only after i.v. administration was there a significant change in heart rate (from 63.7 to 90.2 beats/min). The systolic blood pressure rose from 115.1 to 119.6 mm Hg and the diastolic blood pressure from 68.3 to 78.3 mm Hg.

PubMedSearch : Ensing_1989_Eur.J.Clin.Pharmacol_36_189
PubMedID: 2524387

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Citations formats

Ensing K, de Zeeuw RA, Nossent GD, Koeter GH, Cornelissen PJ (1989)
Pharmacokinetics of ipratropium bromide after single dose inhalation and oral and intravenous administration
European Journal of Clinical Pharmacology 36 :189

Ensing K, de Zeeuw RA, Nossent GD, Koeter GH, Cornelissen PJ (1989)
European Journal of Clinical Pharmacology 36 :189