| Title : Effects of sublethal concentrations of the antifouling biocide Sea-Nine on biochemical parameters of the marine polychaete Perinereis aibuhitensis - Eom_2019_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_222_125 |
| Author(s) : Eom HJ , Haque MN , Nam SE , Lee DH , Rhee JS |
| Ref : Comparative Biochemistry & Physiology C Toxicol Pharmacol , 222 :125 , 2019 |
| Abstract : Sea-Nine 211 is an emerging biocide that has an adverse impact on aquatic environments. In this study, the marine polychaete Perinereis aibuhitensis was exposed to Sea-Nine (0.1, 1, and 10mugL(-1)), and acute toxicity and biochemical responses such as changes in the intracellular contents of malondialdehyde (MDA) and glutathione (GSH) and enzymatic activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), and acetylcholinesterase (AChE) were evaluated over a period of 14 d. Determined median lethal doses, LC50 were 268mugL(-1), 142mugL(-1), and 55mugL(-1) at 24h, 96h, and 14 d, respectively. The MDA content increased significantly in a dose- and time-dependent manner, indicative of lipid peroxidation-related oxidative damage. Significantly higher intracellular GSH levels and antioxidant defense-related enzyme (CAT, SOD, GPx, GR, and GST) activities were observed after exposure to 10mugL(-1) Sea-Nine. In contrast, Sea-Nine treatment significantly reduced AChE activity at the highest concentration of Sea-Nine used (10mugL(-1)). Taken together, these results indicate that sublethal concentrations of Sea-Nine are toxic to marine polychaetes through potential lipid peroxidation, induction of oxidative stress, and modulation of the cholinergic system. Our results can contribute to biomonitoring of aquatic environments and ecotoxicological research through the measurements of polychaete cellular defenses against waterborne biocides. |
| ESTHER : Eom_2019_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_222_125 |
| PubMedSearch : Eom_2019_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_222_125 |
| PubMedID: 31055069 |
Eom HJ, Haque MN, Nam SE, Lee DH, Rhee JS (2019)
Effects of sublethal concentrations of the antifouling biocide Sea-Nine on biochemical parameters of the marine polychaete Perinereis aibuhitensis
Comparative Biochemistry & Physiology C Toxicol Pharmacol
222 :125
Eom HJ, Haque MN, Nam SE, Lee DH, Rhee JS (2019)
Comparative Biochemistry & Physiology C Toxicol Pharmacol
222 :125