Erickson_1995_J.Pharm.Biomed.Anal_13_567

Reference

Title : Identification of a new by-product detected in metoprolol tartrate - Erickson_1995_J.Pharm.Biomed.Anal_13_567
Author(s) : Erickson M , Karlsson KE , Lamm B , Larsson S , Svensson LA , Vessman J
Ref : J Pharm Biomed Anal , 13 :567 , 1995
Abstract :

A new impurity has been found in some batches of metoprolol tartrate. As the amount exceeded 0.1% it was of interest to deduce the structure. Techniques involved in solving the problem were LC, LC-MS and GC-MS. The LC systems showed that the impurity and metoprolol behaved differently to modifications of the mobile phase, indicating that there were differences in the functional groups. LC-MS was used to determine the molecular weight, which was 74 mass units higher than metoprolol. A hydrogen-deuterium shift technique using micro column LC-MS gave the information that three hydrogen atoms were bound to heteroatoms, i.e. one more than in metoprolol. This led to the conclusion that the impurity had three extra carbon and two extra oxygen atoms. It was supposedly a by-product in the synthesis. Knowledge of the synthesis steps for beta-receptor blocking drugs suggested three possible structures. Two were independently synthesized and one of these was found to be identical to the impurity.

PubMedSearch : Erickson_1995_J.Pharm.Biomed.Anal_13_567
PubMedID: 9696571

Related information

Citations formats

Erickson M, Karlsson KE, Lamm B, Larsson S, Svensson LA, Vessman J (1995)
Identification of a new by-product detected in metoprolol tartrate
J Pharm Biomed Anal 13 :567

Erickson M, Karlsson KE, Lamm B, Larsson S, Svensson LA, Vessman J (1995)
J Pharm Biomed Anal 13 :567