| Title : Insecticidal, antifeedant and acetylcholinesterase inhibitory activity of sesquiterpenoids derived from eudesmane, their molecular docking and QSAR - Evelyn_2024_Pestic.Biochem.Physiol_201_105841 |
| Author(s) : Evelyn MN , Edgar PN , Soledad QC , Carlos CA , Alejandro MV , Julio AE |
| Ref : Pestic Biochem Physiol , 201 :105841 , 2024 |
| Abstract : This work evaluated the insecticidal, antifeedant and AChE inhibitory activity of compounds with eudesmane skeleton. The insecticidal activity was tested against larvae of Drosophila melanogaster and Cydia pomonella, the compounds 3 and 4 were the most active (LC(50) of 104.2 and 106.7 microM; 82.0 and 84.4 microM, respectively). Likewise, the mentioned compounds were those that showed the highest acetylcholinesterase inhibitory activity, with IC(50) of 0.26 +/- 0.016 and 0.77 +/- 0.016 microM, respectively. Enzyme kinetic studies, as well as molecular docking, show that the compounds would be non-competitive inhibitors of the enzyme. The antifeedant activity on Plodia interpunctella larvae showed an antifeedant index (AI) of 99% at 72 h for compounds 16, 27 and 20. The QSAR studies show that the properties associated with the polarity of the compounds would be responsible for the biological activities found. |
| ESTHER : Evelyn_2024_Pestic.Biochem.Physiol_201_105841 |
| PubMedSearch : Evelyn_2024_Pestic.Biochem.Physiol_201_105841 |
| PubMedID: 38685257 |
Evelyn MN, Edgar PN, Soledad QC, Carlos CA, Alejandro MV, Julio AE (2024)
Insecticidal, antifeedant and acetylcholinesterase inhibitory activity of sesquiterpenoids derived from eudesmane, their molecular docking and QSAR
Pestic Biochem Physiol
201 :105841
Evelyn MN, Edgar PN, Soledad QC, Carlos CA, Alejandro MV, Julio AE (2024)
Pestic Biochem Physiol
201 :105841