Fan_2009_Zhong.Nan.Da.Xue.Xue.Bao.Yi.Xue.Ban_34_1036

OBJECTIVE: To determine the effects of prostaglandin E(2) alone and the combination with omeprazole for poisoning related acute mucosal lesion. METHODS: Forty-two healthy SD rats were randomly divided into 7 groups: control group (control) , methamidophos poisoning model group (intox), 10 mg/kg omeprazole group (ome1), 50 mg/kg omeprazole group (ome2), 10 microg/kg prostaglandin E(2) group (PG1), 50 microg/kg prostaglandin E(2) group (PG2), 10 microg/kg prostaglandin E(2) combined with 10 mg/kg omeprazole group (union). The gastric ulcer index was counted and the content of serum cholinesterase, endothelin, and tumor necrosis factor were measured, and dependability was analyzed. RESULTS: There was no obvious difference between the prostaglandin group and the poisoning model group in gastric ulcer index, endothelin, and tumor necrosis factor. The omeprazole alone and the combination treatment could improve the acute gastric mucosa lesion induced by methamidophos poisoning. CONCLUSION: Prostaglandin E(2) alone can not obviously improve the acute gastric mucosa lesion by methamidophos poisoning. The combination with omeprazole may be a promising treatment.