Fan_2024_J.Nat.Prod__

Reference

Title : Penicilloneines A and B, Quinolone-Citrinin Hybrids from a Starfish-Derived Penicillium sp - Fan_2024_J.Nat.Prod__
Author(s) : Fan H , Shao XH , Zhang ZK , Ni C , Feng C , Wei X , Zhu JQ , Li XH , Zhang CX
Ref : Journal of Natural Products , : , 2024
Abstract :

Penicilloneines A (1) and B (2) are the first reported quinolone-citrinin hybrids. They were isolated from the starfish-derived fungus Penicillium sp. GGF16-1-2, and their structures were elucidated using spectroscopic, chemical, computational, and single-crystal X-ray diffraction methods. Penicilloneines A (1) and B (2) share a common 4-hydroxy-1-methyl-2(1H)-quinolone unit; however, they differ in terms of citrinin moieties, and these two units are linked via a methylene bridge. Penicilloneines A (1) and B (2) exhibited antifungal activities against Colletotrichum gloeosporioides, with lethal concentration 50 values of 0.02 and 1.51 microg/mL, respectively. A mechanistic study revealed that 1 could inhibit cell growth and promote cell vacuolization and consequent disruption of the fungal cell walls via upregulating nutrient-related hydrolase genes, including putative hydrolase, acetylcholinesterase, glycosyl hydrolase, leucine aminopeptidase, lipase, and beta-galactosidase, and downregulating their synthase genes 3-carboxymuconate cyclase, pyruvate decarboxylase, phosphoketolase, and oxalate decarboxylase.

PubMedSearch : Fan_2024_J.Nat.Prod__
PubMedID: 38547118

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Citations formats

Fan H, Shao XH, Zhang ZK, Ni C, Feng C, Wei X, Zhu JQ, Li XH, Zhang CX (2024)
Penicilloneines A and B, Quinolone-Citrinin Hybrids from a Starfish-Derived Penicillium sp
Journal of Natural Products :

Fan H, Shao XH, Zhang ZK, Ni C, Feng C, Wei X, Zhu JQ, Li XH, Zhang CX (2024)
Journal of Natural Products :