Title : Senolytics prevent age-associated changes in female mice brain - Faria_2024_Neurosci.Lett_826_137730 |
Author(s) : Faria OW , de Aguiar MSS , de Mello JE , Alvez FL , Luduvico KP , Garcia DN , Schneider A , Masternak MM , Spanevello RM , Stefanello FM |
Ref : Neuroscience Letters , 826 :137730 , 2024 |
Abstract :
PURPOSE: Considering that the combination of dasatinib and quercetin (D + Q) demonstrated a neuroprotective action, as well as that females experience a decline in hormonal levels during aging and this is linked to increased susceptibility to Alzheimer's disease, in this study we evaluated the effect of D + Q on inflammatory and oxidative stress markers and on acetylcholinesterase and Na(+), K(+)-ATPase activities in brain of female mice. METHODS: Female C57BL/6 mice were divided in Control and D (5 mg/kg) + Q (50 mg/kg) treated. Treatment was administered via gavage for three consecutive days every two weeks starting at 30 days of age. The animals were euthanized at 6 months of age and at 14 months of age. RESULTS: Results indicate an increase in reactive species (RS), thiol content and lipid peroxidation followed by a reduction in nitrite levels and superoxide dismutase, catalase and glutathione S-transferase activity in the brain of control animals with age. D+Q protected against age-associated increase in RS and catalase activity reduction. Acetylcholinesterase activity was increased, while Na(+), K(+)-ATPase activity was reduced at 14 months of age and D+Q prevented this reduction. CONCLUSION: These data demonstrate that D+Q can protect against age-associated neurochemical alterations in the female brain. |
PubMedSearch : Faria_2024_Neurosci.Lett_826_137730 |
PubMedID: 38485080 |
Faria OW, de Aguiar MSS, de Mello JE, Alvez FL, Luduvico KP, Garcia DN, Schneider A, Masternak MM, Spanevello RM, Stefanello FM (2024)
Senolytics prevent age-associated changes in female mice brain
Neuroscience Letters
826 :137730
Faria OW, de Aguiar MSS, de Mello JE, Alvez FL, Luduvico KP, Garcia DN, Schneider A, Masternak MM, Spanevello RM, Stefanello FM (2024)
Neuroscience Letters
826 :137730