Fayez_1992_Fundam.Appl.Toxicol_18_155

Reference

Title : Acute toxic effects of oxamyl in the rat - Fayez_1992_Fundam.Appl.Toxicol_18_155
Author(s) : Fayez V , Kilgore WW
Ref : Fundamental & Applied Toxicology , 18 :155 , 1992
Abstract :

The effects of single acute oral doses of 1, 2.1, and 3.5 mg/kg oxamyl (a carbamate insecticide) on selected biochemical parameters in male Sprague-Dawley rats were investigated. The animals exhibited significantly decreased weight gain when compared to control animals. The compound inhibited brain and blood acetylcholinesterase significantly in the first few hours of exposure. Liver glucose-6-phosphatase was inhibited substantially after 7 and 4 days at the levels of 2.1 and 3.5 mg/kg, respectively. Maximum inhibition of liver succinic acid dehydrogenase was noted after 1 day at the level of 1 mg/kg and after 6 hr at the level of 2.1 and 3.5 mg/kg. Significant changes in serum total lipids and glucose were observed when oxamyl was given at 2.1 and 3.5 mg/kg, but serum protein was not affected at any dose level. However, the absence of statistically significant effects between Days 7 and 14 in most of the investigated parameters is indicative of an overall moderate degree of toxicity of oxamyl following acute oral administration of the selected doses.

PubMedSearch : Fayez_1992_Fundam.Appl.Toxicol_18_155
PubMedID: 1318238

Related information

Inhibitor Oxamyl

Citations formats

Fayez V, Kilgore WW (1992)
Acute toxic effects of oxamyl in the rat
Fundamental & Applied Toxicology 18 :155

Fayez V, Kilgore WW (1992)
Fundamental & Applied Toxicology 18 :155