| Title : Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B - Feng_2005_Bioorg.Med.Chem.Lett_15_523 |
| Author(s) : Feng S , Xia Y , Han D , Zheng C , He X , Tang X , Bai D |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :523 , 2005 |
|
Abstract :
By targeting dual active sites of AChE, a number of new derivatives of HupB have been synthesized and tested as acetylcholinesterase inhibitors. The most potent compound, bis-HupB 5b is 72-fold more potent in AChE inhibition and 79-fold more selective for AChE versus BChE than HupB. |
| PubMedSearch : Feng_2005_Bioorg.Med.Chem.Lett_15_523 |
| PubMedID: 15664805 |
Feng S, Xia Y, Han D, Zheng C, He X, Tang X, Bai D (2005)
Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B
Bioorganic & Medicinal Chemistry Lett
15 :523
Feng S, Xia Y, Han D, Zheng C, He X, Tang X, Bai D (2005)
Bioorganic & Medicinal Chemistry Lett
15 :523