| Title : Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors - Feng_2005_J.Med.Chem_48_655 |
| Author(s) : Feng S , Wang Z , He X , Zheng S , Xia Y , Jiang H , Tang X , Bai D |
| Ref : Journal of Medicinal Chemistry , 48 :655 , 2005 |
|
Abstract :
By targeting dual active sites of AChE, a series of bis-huperzine B analogues with various lengths of the tether were designed, synthesized, and tested for their inhibition and selectivity. The most potent bis-huperzine B (5g) exhibited 3900-fold increase in AChE inhibition and 930-fold greater in selectivity for AChE vs BuChE than its parent huperzine B. |
| PubMedSearch : Feng_2005_J.Med.Chem_48_655 |
| PubMedID: 15689148 |
Feng S, Wang Z, He X, Zheng S, Xia Y, Jiang H, Tang X, Bai D (2005)
Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors
Journal of Medicinal Chemistry
48 :655
Feng S, Wang Z, He X, Zheng S, Xia Y, Jiang H, Tang X, Bai D (2005)
Journal of Medicinal Chemistry
48 :655