Feng_2018_Insect.Biochem.Mol.Biol_92_30

Reference

Title : Carboxylesterase genes in pyrethroid resistant house flies, Musca domestica - Feng_2018_Insect.Biochem.Mol.Biol_92_30
Author(s) : Feng X , Li M , Liu N
Ref : Insect Biochemistry & Molecular Biology , 92 :30 , 2018
Abstract :

Carboxylesterases are one of the major enzyme families involved in the detoxification of pyrethroids. Up-regulation of carboxylesterase genes is thought to be a major component of insecticide resistant mechanisms in insects. Based on the house fly transcriptome and genome database, a total of 39 carboxylesterase genes of different functional clades have been identified in house flies. In this study, eleven of these genes were found to be significantly overexpressed in the resistant ALHF house fly strain compared with susceptible aabys and wild-type CS strains. Eight up-regulated carboxylesterase genes with their expression levels were further induced to a higher level in response to permethrin treatments, indicating that constitutive and inductive overexpression of carboxylesterases are co-responsible for the enhanced detoxification of insecticides. Spatial expression studies revealed these up-regulated genes to be abundantly distributed in fat bodies and genetically mapped on autosome 2 or 3 of house flies, and their expression could be regulated by factors on autosome 1, 2 and 5. Taken together, these results demonstrate that multiple carboxylesterase genes are co-upregulated in resistant house flies, providing further evidence for their involvement in the detoxification of insecticides and development of insecticide resistance.

PubMedSearch : Feng_2018_Insect.Biochem.Mol.Biol_92_30
PubMedID: 29154832

Related information

Citations formats

Feng X, Li M, Liu N (2018)
Carboxylesterase genes in pyrethroid resistant house flies, Musca domestica
Insect Biochemistry & Molecular Biology 92 :30

Feng X, Li M, Liu N (2018)
Insect Biochemistry & Molecular Biology 92 :30