Fernandez_2017_Neuropsychopharmacology_42_512

Reference

Title : Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity - Fernandez_2017_Neuropsychopharmacology_42_512
Author(s) : Fernandez SP , Muzerelle A , Scotto-Lomassese S , Barik J , Gruart A , Delgado-Garcia JM , Gaspar P
Ref : Neuropsychopharmacology , 42 :512 , 2017
Abstract :

Serotonin (5-HT) deficiency occurs in a number of brain disorders that affect cognitive function. However, a direct causal relationship between 5-HT hypo-transmission and memory and underlying mechanisms has not been established. We used mice with a constitutive depletion of 5-HT brain levels (Pet1KO mice) to analyze the contribution of 5-HT to different forms of learning and memory. Pet1KO mice exhibited a striking deficit in novel object recognition memory, a hippocampal-dependent task. No alterations were found in tasks for social recognition, procedural learning, or fear memory. Viral delivery of designer receptors exclusively activated by designer drugs was used to selectively silence the activity of 5-HT neurons in the raphe. Inhibition of 5-HT neurons in the median raphe, but not the dorsal raphe, was sufficient to impair object recognition in adult mice. In vivo electrophysiology in behaving mice showed that long-term potentiation in the hippocampus of 5-HT-deficient mice was altered, and administration of the 5-HT1A agonist 8-OHDPAT rescued the memory deficits. Our data suggest that hyposerotonergia selectively affects declarative hippocampal-dependent memory. Serotonergic projections from the median raphe are necessary to regulate object memory and hippocampal synaptic plasticity processes, through an inhibitory control mediated by 5-HT1A receptors.

PubMedSearch : Fernandez_2017_Neuropsychopharmacology_42_512
PubMedID: 27461084

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Citations formats

Fernandez SP, Muzerelle A, Scotto-Lomassese S, Barik J, Gruart A, Delgado-Garcia JM, Gaspar P (2017)
Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity
Neuropsychopharmacology 42 :512

Fernandez SP, Muzerelle A, Scotto-Lomassese S, Barik J, Gruart A, Delgado-Garcia JM, Gaspar P (2017)
Neuropsychopharmacology 42 :512