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Ferre_2002_Clin.Biochem_35_197

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Title : Paraoxonase Gln-Arg(192) and Leu-Met(55) gene polymorphisms and enzyme activity in a population with a low rate of coronary heart disease - Ferre_2002_Clin.Biochem_35_197
Author(s) : Ferre N , Tous M , Paul A , Zamora A , Vendrell JJ , Bardaji A , Camps J , Richart C , Joven J
Ref : Clinical Biochemistry , 35 :197 , 2002
Abstract :

OBJECTIVES: To assess whether paraoxonase (PON1) polymorphisms at positions 55 and 192 and/or their phenotypic expressions influence the risk of myocardial infarction (MI) in Spanish population. DESIGN AND
METHODS: Two hundred and fifteen male survivors of a MI and their age-matched controls were included in the study. Lipids, apolipoproteins (apo) A-I and B, PON1 activity on paraoxon and phenylacetate and PON1 polymorphisms were determined.
RESULTS: Genotype distribution was similar in patients and controls. Enzyme activities were lower in patients, but multiple logistic regression analysis did not show any independent association with a higher risk of MI. CONCLUSION: None of the PON1 polymorphisms or their corresponding measured activities are independent risk factors for MI in our population.
PubMedSearch : Ferre_2002_Clin.Biochem_35_197
PubMedID: 12074827

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Citations formats

Ferre N, Tous M, Paul A, Zamora A, Vendrell JJ, Bardaji A, Camps J, Richart C, Joven J (2002)
Paraoxonase Gln-Arg(192) and Leu-Met(55) gene polymorphisms and enzyme activity in a population with a low rate of coronary heart disease
Clinical Biochemistry 35 :197

Ferre N, Tous M, Paul A, Zamora A, Vendrell JJ, Bardaji A, Camps J, Richart C, Joven J (2002)
Clinical Biochemistry 35 :197