Ferreira_2022_Environ.Toxicol.Pharmacol__103870

Reference

Title : Environmentally relevant Manganese concentrations evoke anxiety phenotypes in adult zebrafish - Ferreira_2022_Environ.Toxicol.Pharmacol__103870
Author(s) : Ferreira SA , Loreto JS , Dos Santos MM , Barbosa NV
Ref : Environ Toxicol Pharmacol , :103870 , 2022
Abstract :

Manganese (Mn) is an essential metal for living organisms. However, the excess of Mn can be toxic, especially for the central nervous system. Herein, we used adult zebrafish as model organism to investigate the relationship of an environmentally relevant Mn exposure with the onset of neurobehavioral disturbances and brain biochemical alterations. Fish were exposed to MnCl(2) at 0.5, 2.0, 7.5 and 15.0mg/L for 96h, and after submitted to trials for examining exploratory, locomotor and anxiety-related behaviors. The neurobehavioral parameters were followed by the analyses of cell viability, Mn accumulation and acetylcholinesterase activity in the brain, and whole-body cortisol levels. By Novel tank, Light dark and Social preference test, we found that the exposure to Mn, along with locomotor deficits induced anxiety-like phenotypes in zebrafish. Most of these behavioral changes were evoked by the highest concentrations, which also caused cell viability loss, higher accumulation of Mn and increased AChE activity in the brain, and an increase in the whole-body cortisol content. Our findings demonstrated that zebrafish are quite sensitive to levels of Mn found in the environment, and that the magnitude of the neurotoxic effects may be associated with the levels of manganese accumulated in the brain. Interestingly, we showed that Mn exposure in addition to motor deficits may also cause psychiatric abnormalities, namely anxiety.

PubMedSearch : Ferreira_2022_Environ.Toxicol.Pharmacol__103870
PubMedID: 35523392

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Citations formats

Ferreira SA, Loreto JS, Dos Santos MM, Barbosa NV (2022)
Environmentally relevant Manganese concentrations evoke anxiety phenotypes in adult zebrafish
Environ Toxicol Pharmacol :103870

Ferreira SA, Loreto JS, Dos Santos MM, Barbosa NV (2022)
Environ Toxicol Pharmacol :103870