| Title : Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis - Fingerlin_2013_Nat.Genet_45_613 |
| Author(s) : Fingerlin TE , Murphy E , Zhang W , Peljto AL , Brown KK , Steele MP , Loyd JE , Cosgrove GP , Lynch D , Groshong S , Collard HR , Wolters PJ , Bradford WZ , Kossen K , Seiwert SD , du Bois RM , Garcia CK , Devine MS , Gudmundsson G , Isaksson HJ , Kaminski N , Zhang Y , Gibson KF , Lancaster LH , Cogan JD , Mason WR , Maher TM , Molyneaux PL , Wells AU , Moffatt MF , Selman M , Pardo A , Kim DS , Crapo JD , Make BJ , Regan EA , Walek DS , Daniel JJ , Kamatani Y , Zelenika D , Smith K , McKean D , Pedersen BS , Talbert J , Kidd RN , Markin CR , Beckman KB , Lathrop M , Schwarz MI , Schwartz DA |
| Ref : Nat Genet , 45 :613 , 2013 |
|
Abstract :
We performed a genome-wide association study of non-Hispanic, white individuals with fibrotic idiopathic interstitial pneumonias (IIPs; n = 1,616) and controls (n = 4,683), with follow-up replication analyses in 876 cases and 1,890 controls. We confirmed association with TERT at 5p15, MUC5B at 11p15 and the 3q26 region near TERC, and we identified seven newly associated loci (Pmeta = 2.4 x 10(-8) to 1.1 x 10(-19)), including FAM13A (4q22), DSP (6p24), OBFC1 (10q24), ATP11A (13q34), DPP9 (19p13) and chromosomal regions 7q22 and 15q14-15. Our results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs. |
| PubMedSearch : Fingerlin_2013_Nat.Genet_45_613 |
| PubMedID: 23583980 |
Fingerlin TE, Murphy E, Zhang W, Peljto AL, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch D, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Cogan JD, Mason WR, Maher TM, Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Smith K, McKean D, Pedersen BS, Talbert J, Kidd RN, Markin CR, Beckman KB, Lathrop M, Schwarz MI, Schwartz DA (2013)
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
Nat Genet
45 :613
Fingerlin TE, Murphy E, Zhang W, Peljto AL, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch D, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Cogan JD, Mason WR, Maher TM, Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Smith K, McKean D, Pedersen BS, Talbert J, Kidd RN, Markin CR, Beckman KB, Lathrop M, Schwarz MI, Schwartz DA (2013)
Nat Genet
45 :613