Fischer_2002_J.Neurosci_22_3700

Reference

Title : Cyclin-dependent kinase 5 is required for associative learning - Fischer_2002_J.Neurosci_22_3700
Author(s) : Fischer A , Sananbenesi F , Schrick C , Spiess J , Radulovic J
Ref : Journal of Neuroscience , 22 :3700 , 2002
Abstract :

Transient stressful experiences may persistently facilitate associative and nonassociative learning, possibly through alterations of gene expression. Here we identify, by subtractive hybridization, differential expression of the Cdk5 gene in response to stress. The Cdk5 protein is selectively induced in the fibers of septohippocampal cholinergic neurons but not in other regions of prominent Cdk5 production. This upregulation is accompanied by increased Cdk5 kinase activity, which is blocked completely by the Cdk5 inhibitor butyrolactone I. Microinjection of butyrolactone I into the lateral septum and hippocampus prevents the acquisition of conditioned context-dependent fear as well as its stress-induced facilitation. By demonstrating that a transient increase of Cdk5 activity within the septohippocampal system is required for associative learning, an important novel role of Cdk5 has been identified.

PubMedSearch : Fischer_2002_J.Neurosci_22_3700
PubMedID: 11978846

Related information

Citations formats

Fischer A, Sananbenesi F, Schrick C, Spiess J, Radulovic J (2002)
Cyclin-dependent kinase 5 is required for associative learning
Journal of Neuroscience 22 :3700

Fischer A, Sananbenesi F, Schrick C, Spiess J, Radulovic J (2002)
Journal of Neuroscience 22 :3700