Title : Muscarinic receptors in chromaffin cell cultures mediate enhanced phospholipid labeling but not catecholamine secretion - Fisher_1981_J.Neurochem_37_491 |
Author(s) : Fisher SK , Holz RW , Agranoff BW |
Ref : Journal of Neurochemistry , 37 :491 , 1981 |
Abstract :
The addition of either carbachol or muscarinic agonists to cultured bovine adrenal chromaffin cells results in a selective stimulation of phosphatidate (PhA) and phosphatidylinositol (PhI) labeling from 32Pi and [3H]glycerol that can be inhibited by the inclusion of atropine, but not d-tubocurarine. In contrast, increased catecholamine secretion is observed on the addition of carbachol or nicotinic agonists and is inhibited by d-tubocurarine but not by atropine. Added calcium is essential for catecholamine secretion but not for stimulated phospholipid labeling. Chelation of endogenous Ca2+ with EGTA does, however, inhibit the stimulated phospholipid labeling. These results suggest that stimulated phospholipid labeling in the bovine chromaffin cell and catecholamine secretion are separate and distinct processes. |
PubMedSearch : Fisher_1981_J.Neurochem_37_491 |
PubMedID: 7264672 |
Fisher SK, Holz RW, Agranoff BW (1981)
Muscarinic receptors in chromaffin cell cultures mediate enhanced phospholipid labeling but not catecholamine secretion
Journal of Neurochemistry
37 :491
Fisher SK, Holz RW, Agranoff BW (1981)
Journal of Neurochemistry
37 :491