Fisher_1981_J.Neurochem_37_491

Reference

Title : Muscarinic receptors in chromaffin cell cultures mediate enhanced phospholipid labeling but not catecholamine secretion - Fisher_1981_J.Neurochem_37_491
Author(s) : Fisher SK , Holz RW , Agranoff BW
Ref : Journal of Neurochemistry , 37 :491 , 1981
Abstract :

The addition of either carbachol or muscarinic agonists to cultured bovine adrenal chromaffin cells results in a selective stimulation of phosphatidate (PhA) and phosphatidylinositol (PhI) labeling from 32Pi and [3H]glycerol that can be inhibited by the inclusion of atropine, but not d-tubocurarine. In contrast, increased catecholamine secretion is observed on the addition of carbachol or nicotinic agonists and is inhibited by d-tubocurarine but not by atropine. Added calcium is essential for catecholamine secretion but not for stimulated phospholipid labeling. Chelation of endogenous Ca2+ with EGTA does, however, inhibit the stimulated phospholipid labeling. These results suggest that stimulated phospholipid labeling in the bovine chromaffin cell and catecholamine secretion are separate and distinct processes.

PubMedSearch : Fisher_1981_J.Neurochem_37_491
PubMedID: 7264672

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Citations formats

Fisher SK, Holz RW, Agranoff BW (1981)
Muscarinic receptors in chromaffin cell cultures mediate enhanced phospholipid labeling but not catecholamine secretion
Journal of Neurochemistry 37 :491

Fisher SK, Holz RW, Agranoff BW (1981)
Journal of Neurochemistry 37 :491