Flegar-Mestric_1999_Chem.Biol.Interact_119-120_193

Biological variations of total butyrylcholinesterase activity (EC 3.1.1.8) in sera were determined in 993 healthy school children (age 8-19 years) and 2246 healthy adults (20-70 years) in a population from Zagreb, Croatia. Physiological variations corresponding to age and sex and genetically determined changes were studied as the important factors affecting biological variation in total butyrylcholinesterase activity. Based on biological variability, using a non-parametric statistical method, reference intervals for total butyrylcholinesterase activity were produced in order to provide medically reliable evaluation of laboratory results by pediatricians and clinicians in our country.