| Title : Econazole, a blocker of Ca2+ influx, selectively suppresses LTP of EPSPs in hippocampal slices - Forghani_1995_Neurosci.Lett_196_122 |
| Author(s) : Forghani R , Krnjevic K |
| Ref : Neuroscience Letters , 196 :122 , 1995 |
|
Abstract :
Econazole--an agent that suppresses Ca2+ influx triggered by depletion of internal Ca-stores in non-excitable cells--was bath-applied to submerged slices from Sprague-Dawley rats. Econazole (15-20 microM) had no consistent effect on afferent volleys, EPSPs or population spikes; but in seven out of nine slices, it prevented the induction of tetanic long-term potentiation (LTP) of field EPSPS. By contrast, all slices showed a marked LTP of population spikes. Ca2+ influx induced by tetanic depletion of Ca2+ stores may be essential for LTP of excitatory synaptic transmission. |
| PubMedSearch : Forghani_1995_Neurosci.Lett_196_122 |
| PubMedID: 7501238 |
Forghani R, Krnjevic K (1995)
Econazole, a blocker of Ca2+ influx, selectively suppresses LTP of EPSPs in hippocampal slices
Neuroscience Letters
196 :122
Forghani R, Krnjevic K (1995)
Neuroscience Letters
196 :122