| Title : Measurement of feline-specific pancreatic lipase aids in the diagnosis of pancreatitis in cats - Forman_2024_J.Am.Vet.Med.Assoc_262_42 |
| Author(s) : Forman MA , Robertson JE , Shiroma JT , Hostutler RA , Simpson KW , Estrin M , Newman SJ , Corn SC , Buch J , Armstrong PJ |
| Ref : J Am Vet Med Assoc , 262 :42 , 2024 |
| Abstract : OBJECTIVE: To establish a reference interval for a feline-specific pancreatic lipase assay (Spec fPL test; Idexx Laboratories Inc) in healthy cats and determine the sensitivity and specificity of the Spec fPL test in a large group of ill cats with and without pancreatitis. ANIMALS: 41 healthy cats, 141 cats with clinical signs consistent with pancreatitis, and 786 stored sera with known feline pancreatic lipase immunoreactivity (fPLI) concentrations. METHODS: This was a prospective, cross-sectional, nonrandomized study. Based on a detailed review of the medical history and results of physical examination, CBC, serum biochemical profile, urinalysis, abdominal ultrasonography, and clinical outcome, each cat was categorized by 2 board-certified internists masked to the fPLI test results into 1 of 6 categories from definitely pancreatitis to definitely not pancreatitis. RESULTS: The reference interval for the Spec fPL test, determined from the central 95th percentile of results from healthy cats, was fPLI of 0.7 to 3.5 microg/L. An fPLI concentration of <= 5.4 microg/L was determined to be consistent with pancreatitis. With an fPLI of 5.4 microg/L as the diagnostic cutoff, the sensitivity of the Spec fPL test for feline pancreatitis (definitely pancreatitis and probably pancreatitis) was 79.4%, the specificity for cats characterized as probably not pancreatitis and definitely not pancreatitis was 79.7%, and positive and negative predictive values were 69% and 87%, respectively. CLINICAL RELEVANCE: These findings support the use of the Spec fPL test as a valuable diagnostic test for feline pancreatitis. |
| ESTHER : Forman_2024_J.Am.Vet.Med.Assoc_262_42 |
| PubMedSearch : Forman_2024_J.Am.Vet.Med.Assoc_262_42 |
| PubMedID: 38100989 |
Forman MA, Robertson JE, Shiroma JT, Hostutler RA, Simpson KW, Estrin M, Newman SJ, Corn SC, Buch J, Armstrong PJ (2024)
Measurement of feline-specific pancreatic lipase aids in the diagnosis of pancreatitis in cats
J Am Vet Med Assoc
262 :42
Forman MA, Robertson JE, Shiroma JT, Hostutler RA, Simpson KW, Estrin M, Newman SJ, Corn SC, Buch J, Armstrong PJ (2024)
J Am Vet Med Assoc
262 :42