Fostieri_2000_FEBS.Lett_481_127

Reference

Title : The conformation of the main immunogenic region on the alpha-subunit of muscle acetylcholine receptor is affected by neighboring receptor subunits - Fostieri_2000_FEBS.Lett_481_127
Author(s) : Fostieri E , Beeson D , Tzartos SJ
Ref : FEBS Letters , 481 :127 , 2000
Abstract :

Myasthenia gravis (MG) is caused by autoantibodies to the acetylcholine receptor (AChR). Experiments with fetal (alpha(2)betagammadelta) and adult (alpha(2)betaepsilondelta) AChR and with recombinant subunit dimers showed that some monoclonal antibodies (mAbs) against the main immunogenic region (MIR), located on the alpha-subunit of the AChR, bind better to fetal AChR and to alphagamma subunit dimer than to adult AChR and alphaepsilon dimer and equally to both alphabeta and alphadelta. However, other anti-MIR mAbs prefer adult AChR and alphaepsilon dimer, bind well to alphabeta but weakly to alphadelta. These results suggest that the MIR conformation is affected by the neighboring gamma/epsilon- and delta-subunits and may contribute to understanding the antibody specificities in MG.

PubMedSearch : Fostieri_2000_FEBS.Lett_481_127
PubMedID: 10996310

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Citations formats

Fostieri E, Beeson D, Tzartos SJ (2000)
The conformation of the main immunogenic region on the alpha-subunit of muscle acetylcholine receptor is affected by neighboring receptor subunits
FEBS Letters 481 :127

Fostieri E, Beeson D, Tzartos SJ (2000)
FEBS Letters 481 :127