Francis_1999_Neuron_23_247

Reference

Title : Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons - Francis_1999_Neuron_23_247
Author(s) : Francis F , Koulakoff A , Boucher D , Chafey P , Schaar B , Vinet MC , Friocourt G , McDonnell N , Reiner O , Kahn A , McConnell SK , Berwald-Netter Y , Denoulet P , Chelly J
Ref : Neuron , 23 :247 , 1999
Abstract : Recently, we and others reported that the doublecortin gene is responsible for X-linked lissencephaly and subcortical laminar heterotopia. Here, we show that Doublecortin is expressed in the brain throughout the period of corticogenesis in migrating and differentiating neurons. Immunohistochemical studies show its localization in the soma and leading processes of tangentially migrating neurons, and a strong axonal labeling is observed in differentiating neurons. In cultured neurons, Doublecortin expression is highest in the distal parts of developing processes. We demonstrate by sedimentation and microscopy studies that Doublecortin is associated with microtubules (MTs) and postulate that it is a novel MAP. Our data suggest that the cortical dysgeneses associated with the loss of Doublecortin function might result from abnormal cytoskeletal dynamics in neuronal cell development.
ESTHER : Francis_1999_Neuron_23_247
PubMedSearch : Francis_1999_Neuron_23_247
PubMedID: 10399932

Related information

Citations formats

Francis F, Koulakoff A, Boucher D, Chafey P, Schaar B, Vinet MC, Friocourt G, McDonnell N, Reiner O, Kahn A, McConnell SK, Berwald-Netter Y, Denoulet P, Chelly J (1999)
Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons
Neuron 23 :247

Francis F, Koulakoff A, Boucher D, Chafey P, Schaar B, Vinet MC, Friocourt G, McDonnell N, Reiner O, Kahn A, McConnell SK, Berwald-Netter Y, Denoulet P, Chelly J (1999)
Neuron 23 :247