| Title : Amnesia produced by intracerebroventricular injections of hemicholinium-3 in mice was prevented by pretreatment with piracetam-like compounds - Franklin_1986_Pharmacol.Biochem.Behav_25_925 |
| Author(s) : Franklin SR , Sethy VH , Tang AH |
| Ref : Pharmacol Biochem Behav , 25 :925 , 1986 |
|
Abstract :
Intracerebroventricular (ICV) injections of hemicholinium-3 (HC-3) to mice before the training trial in a passive avoidance task produced an amnesic effect at the 24-hour retention test. Pretreatment by IP injection of piracetam, etiracetam, or pramiracetam, 30 minutes before HC-3 injections antagonized the amnesic effects of HC-3. Pretreatment with choline was not effective. The depletion of cerebral acetylcholine by the HC-3 injection was not prevented by piracetam or etiracetam. |
| PubMedSearch : Franklin_1986_Pharmacol.Biochem.Behav_25_925 |
| PubMedID: 3786350 |
Franklin SR, Sethy VH, Tang AH (1986)
Amnesia produced by intracerebroventricular injections of hemicholinium-3 in mice was prevented by pretreatment with piracetam-like compounds
Pharmacol Biochem Behav
25 :925
Franklin SR, Sethy VH, Tang AH (1986)
Pharmacol Biochem Behav
25 :925