| Title : Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization - Fredrickson_2003_Brain.Res_979_245 |
| Author(s) : Fredrickson P , Boules M , Yerbury S , Richelson E |
| Ref : Brain Research , 979 :245 , 2003 |
|
Abstract :
Neurotensin is a tridecapeptide that participates in regulation of dopaminergic pathways implicated in nicotine addiction. Previously, we showed that one of our brain-penetrating neurotensin analogs, NT69L, blocks nicotine-induced locomotor sensitization. The present work demonstrates that NT69L blocks both the initiation and the expression of sensitization. In addition chronic NT69L administration blocked the acute effects of nicotine on norepinephrine and serotonin in prefrontal cortex. |
| PubMedSearch : Fredrickson_2003_Brain.Res_979_245 |
| PubMedID: 12850594 |
Fredrickson P, Boules M, Yerbury S, Richelson E (2003)
Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization
Brain Research
979 :245
Fredrickson P, Boules M, Yerbury S, Richelson E (2003)
Brain Research
979 :245