Title : Are the effects of gestational stress on motor development and cerebellar cholinesterase activity mediated prenatally? - Fride_1986_Int.J.Dev.Neurosci_4_407 |
Author(s) : Fride E , Soreq H , Weinstock M |
Ref : Int J Developmental Neuroscience , 4 :407 , 1986 |
Abstract :
Prenatal random noise and light stress retards early motor development in the rat. To determine whether this delay is pre- or postnatally mediated and whether the developing cerebellum may play a role in the delay, rats were subjected to this form of stress and their offspring were fostered or cross-fostered onto control rats and vice versa. Their motor development was assessed by a series of behavioral tests between birth and day 10 of life. Prenatally stressed pups (Eo), whether reared by stressed (Em) or control mothers (Cm), showed a retardation in motor development. However, stressed pups matured earlier when reared by a control mother than by a stressed dam. Control pups (Co) raised by stressed mothers showed normal behavioral development. Cerebellar cholinesterase activity, which has been shown to undergo characteristic alterations with normal maturation, did not differ between stressed and control pups at birth. However, on day 10, cholinesterase activity was lower in EmCo than in CmCo pups, whereas that in CmEo and EmEo pups did not differ significantly from controls. It is concluded that three effects of random noise and light stress during pregnancy may be distinguished: (1) A prenatal effect as expressed by a delay in motor development, (2) a postnatal (rearing) effect on motor development and (3) a rearing effect expressed as a decrease in cerebellar ChE activity. |
PubMedSearch : Fride_1986_Int.J.Dev.Neurosci_4_407 |
PubMedID: 3455601 |
Fride E, Soreq H, Weinstock M (1986)
Are the effects of gestational stress on motor development and cerebellar cholinesterase activity mediated prenatally?
Int J Developmental Neuroscience
4 :407
Fride E, Soreq H, Weinstock M (1986)
Int J Developmental Neuroscience
4 :407