| Title : Loss of cholinergic neurons in the rat neocortex produces deficits in passive avoidance learning - Friedman_1983_Pharmacol.Biochem.Behav_19_309 |
| Author(s) : Friedman E , Lerer B , Kuster J |
| Ref : Pharmacol Biochem Behav , 19 :309 , 1983 |
|
Abstract :
Bilateral kainic acid lesions of the ventral globus pallidus produced a significant and selective cortical decrease in choline acetyltransferase activity in the rat brain. When lesioned and control subjects were compared on performance of a step-through passive avoidance task, lesioned rats showed a marked retention deficit 24 hr after the initial training trial. This experimentally-induced memory deficit associated with a cortical cholinergic neuronal loss resembles the deficits in senile dementia of the Alzheimer type and may provide a useful animal model for studying the disease. |
| PubMedSearch : Friedman_1983_Pharmacol.Biochem.Behav_19_309 |
| PubMedID: 6634880 |
Friedman E, Lerer B, Kuster J (1983)
Loss of cholinergic neurons in the rat neocortex produces deficits in passive avoidance learning
Pharmacol Biochem Behav
19 :309
Friedman E, Lerer B, Kuster J (1983)
Pharmacol Biochem Behav
19 :309