| Title : FR901469, a novel antifungal antibiotic from an unidentified fungus No.11243. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological properties - Fujie_2000_J.Antibiot.(Tokyo)_53_912 |
| Author(s) : Fujie A , Iwamoto T , Muramatsu H , Okudaira T , Nitta K , Nakanishi T , Sakamoto K , Hori Y , Hino M , Hashimoto S , Okuhara M |
| Ref : J Antibiot (Tokyo) , 53 :912 , 2000 |
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Abstract :
FR901469 is a novel antifungal antibiotic produced by an unidentified fungus No.11243. This compound was isolated from the culture broth by solvent extraction, HP-20 and YMC ODS gel column chromatography, and lyophilization. FR901469 is a white powder which melts at 182 approximately 187 degrees C and possesses the molecular formula C71H116N14O23. This compound has good water solubility. FR901469 inhibited the activity of 1,3-beta-glucan synthase from Candida albicans with an IC50 value of 0.05 microg/ml, and displayed greater inhibitory activity than other 1,3-beta-glucan synthase inhibitors such as, WF11899A, echinocandin B, aculeacin A, and papulacandin B. |
| PubMedSearch : Fujie_2000_J.Antibiot.(Tokyo)_53_912 |
| PubMedID: 11099224 |
| Gene_locus related to this paper: blob1-frbd , blob1-frbe |
| Gene_locus | blob1-frbd blob1-frbe |
Fujie A, Iwamoto T, Muramatsu H, Okudaira T, Nitta K, Nakanishi T, Sakamoto K, Hori Y, Hino M, Hashimoto S, Okuhara M (2000)
FR901469, a novel antifungal antibiotic from an unidentified fungus No.11243. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological properties
J Antibiot (Tokyo)
53 :912
Fujie A, Iwamoto T, Muramatsu H, Okudaira T, Nitta K, Nakanishi T, Sakamoto K, Hori Y, Hino M, Hashimoto S, Okuhara M (2000)
J Antibiot (Tokyo)
53 :912