Gallowitsch-Puerta_2007_Life.Sci_80_2325

Reference

Title : Neuro-immune interactions via the cholinergic anti-inflammatory pathway - Gallowitsch-Puerta_2007_Life.Sci_80_2325
Author(s) : Gallowitsch-Puerta M , Pavlov VA
Ref : Life Sciences , 80 :2325 , 2007
Abstract :

The overproduction of TNF and other cytokines is associated with the pathophysiology of numerous diseases. Controlling cytokine synthesis and release is critical for preventing unrestrained inflammation and maintaining health. Recent studies identified an efferent vagus nerve-based mechanism termed "the cholinergic anti-inflammatory pathway" that controls cytokine production and inflammation. Here we review current advances related to the role of this pathway in neuro-immune interactions that prevent excessive inflammation. Experimental evidence indicates that vagus nerve cholinergic anti-inflammatory signaling requires alpha7 nicotinic acetylcholine receptors expressed on non-neuronal cytokine-producing cells. Alpha7 nicotinic acetylcholine receptor agonists inhibit cytokine release and protect animals in a variety of experimental lethal inflammatory models. Knowledge related to the cholinergic anti-inflammatory pathway can be exploited in therapeutic approaches directed towards counteracting abnormal chronic and hyper-activated inflammatory responses.

PubMedSearch : Gallowitsch-Puerta_2007_Life.Sci_80_2325
PubMedID: 17289087

Related information

Citations formats

Gallowitsch-Puerta M, Pavlov VA (2007)
Neuro-immune interactions via the cholinergic anti-inflammatory pathway
Life Sciences 80 :2325

Gallowitsch-Puerta M, Pavlov VA (2007)
Life Sciences 80 :2325