Garenc_2001_J.Appl.Physiol_91_1334

Reference

Title : Evidence of LPL gene-exercise interaction for body fat and LPL activity: the HERITAGE Family Study - Garenc_2001_J.Appl.Physiol_91_1334
Author(s) : Garenc C , Perusse L , Bergeron J , Gagnon J , Chagnon YC , Borecki IB , Leon AS , Skinner JS , Wilmore JH , Rao DC , Bouchard C
Ref : J Appl Physiol , 91 :1334 , 2001
Abstract :

Evidence of a gene-exercise interaction for traits related to body composition is limited. Here, the association between the lipoprotein lipase (LPL) S447X polymorphism and changes in body mass index, fat mass, percent body fat, abdominal visceral fat measured by computed tomography, and post-heparin plasma LPL activity in response to 20 wk of endurance training was investigated in 741 adult white and black subjects. Changes were compared between carriers and noncarriers of the X447 allele after adjustment for the effects of age and pretraining values. No evidence of association was observed in men. However, white women carrying the X447 allele exhibited greater reductions of body mass index (P = 0.01), fat mass (P = 0.01), and percent body fat (P = 0.03); in black women, the carriers exhibited a greater reduction of abdominal visceral fat (P = 0.05) and a greater increase in post-heparin LPL activity (P = 0.02). These results suggest that the LPL S447X polymorphism influences the training-induced changes in body fat and post-heparin LPL activity in women but not in men.

PubMedSearch : Garenc_2001_J.Appl.Physiol_91_1334
PubMedID: 11509533

Related information

Citations formats

Garenc C, Perusse L, Bergeron J, Gagnon J, Chagnon YC, Borecki IB, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C (2001)
Evidence of LPL gene-exercise interaction for body fat and LPL activity: the HERITAGE Family Study
J Appl Physiol 91 :1334

Garenc C, Perusse L, Bergeron J, Gagnon J, Chagnon YC, Borecki IB, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C (2001)
J Appl Physiol 91 :1334