Title : Rapid simultaneous genotyping of the frequent butyrylcholinesterase variants Asp70Gly and Ala539Thr with fluorescent hybridization probes - Gatke_2002_Scand.J.Clin.Lab.Invest_62_375 |
Author(s) : Gatke MR , Viby-Mogensen J , Bundgaard JR |
Ref : Scand J Clin Lab Invest , 62 :375 , 2002 |
Abstract :
BACKGROUND: The clinically important variants of butyrylcholinesterase (BChE) are the A- (Asp70Gly) and K-variants (Ala539Thr), which are common among Caucasians. These variants are associated with abnormal drug metabolism during anaesthesia, which leads to a prolonged neuromuscular block following administration of the neuromuscular blocking agents, mivacurium and succinylcholine. In addition, the K-variant has been proposed to be associated with Alzheimer's disease together with apolipoprotein E epsilon4. To facilitate diagnostics, we set out to establish a rapid and simple method for simultaneous genotyping of the A- and K-variants. |
PubMedSearch : Gatke_2002_Scand.J.Clin.Lab.Invest_62_375 |
PubMedID: 12387584 |
Mutation | D70G_human-BCHE A539T_human-BCHE |
Gatke MR, Viby-Mogensen J, Bundgaard JR (2002)
Rapid simultaneous genotyping of the frequent butyrylcholinesterase variants Asp70Gly and Ala539Thr with fluorescent hybridization probes
Scand J Clin Lab Invest
62 :375
Gatke MR, Viby-Mogensen J, Bundgaard JR (2002)
Scand J Clin Lab Invest
62 :375